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KMID : 0358420080510121528
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Korean Journal of Obstetrics and Gynecology
2008 Volume.51 No. 12 p.1528 ~ p.1532
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Anti-Yo-associated paraneoplastic cerebellar degeneration in a patient with chemotherapy-responsive ovarian cancer: A case report with a review of Literatures
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Song Seung-Hun
Park Choong-Hak
Park Jin-Wan
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Abstract
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Paraneoplastic cerebellar degeneration (PCD), the one of rare paraneoplastic syndromes, refer to clinical disorders associated mostly with lung, ovarian and breast cancer, but not directly caused by cancer or its metastasis. PCD is a condition whereby the Purkinje cells of the cerebellar cortex are damaged secondary to an autoimmune process. We report here on the case of PCD of subacute onset in a patient at 7 months after surgery for ovarian cancer. Although the cases of PCD has rarely been reported, the present case appears to be the first in Korea in which PCD was associated with anti-Yo antibody in patient with chemotherapy-responsive ovarian cancer. The clinical significance of PCD associated with anti-Yo antibody is reviewed.
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KEYWORD
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Paraneoplastic cerebellar degeneration, Anti-Yo antibody, Ovarian cancer
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